MRSA Research Center

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For Clinical Researchers – Clinical References

2015
Gaupp R, Lei S, Reed JM, Peisker H, Boyle-Vavra S, Bayer AS, Bischoff M,
Herrmann M, Daum RS, Powers R, Somerville GA. Staphylococcus aureus metabolic adaptations during the transition from a daptomycin susceptibility phenotype to a daptomycin nonsusceptibility phenotype. Antimicrob Agents Chemother. 2015 Jul;59(7):4226-38.

Miller LG, Daum RS, Chambers HF. Antibacterial Treatment for Uncomplicated
Skin Infections. N Engl J Med. 2015 Jun 18;372(25):2460.

Miller LG, Daum RS, Creech CB, Young D, Downing MD, Eells SJ, Pettibone S,
Hoagland RJ, Chambers HF; DMID 07-0051 Team. Clindamycin versus
trimethoprim-sulfamethoxazole for uncomplicated skin infections. N Engl J Med.
2015 Mar 19;372(12):1093-103.

Zhao F, Cheng BL, Boyle-Vavra S, Alegre ML, Daum RS, Chong AS, Montgomery CP. Proteomic Identification of saeRS-Dependent Targets Critical for Protective Humoral Immunity against Staphylococcus aureus Skin Infection. Infect Immun. 2015 Sep;83(9):3712-21.

Hemmige V, McNulty M, Silverman E, David MZ. Recurrent skin and soft tissue
infections in HIV-infected patients during a 5-year period: incidence and risk
factors in a retrospective cohort study. BMC Infect Dis. 2015 Oct 26;15:455.

Morgan E, David MZ. Do citation trends reflect epidemiologic patterns? Assessing MRSA, emerging and re-emerging pathogens, 1963-2014. BMC Infect Dis. 2015 Oct 26;15:460.

Carrel M, Perencevich EN, David MZ. USA300 Methicillin-Resistant Staphylococcus aureus, United States, 2000-2013. Emerg Infect Dis. 2015
Nov;21(11):1973-80.

David MZ, Acree ME, Sieth JJ, Boxrud DJ, Dobbins G, Lynfield R, Boyle-Vavra S, Daum RS. Pediatric Staphylococcus aureus Isolate Genotypes and Infections from the Dawn of the Community-Associated Methicillin-Resistant S. aureus Epidemic Era in Chicago, 1994 to 1997. J Clin Microbiol. 2015 Aug;53(8):2486-91.

Montgomery CP, David MZ, Daum RS. Host factors that contribute to recurrent
staphylococcal skin infection. Curr Opin Infect Dis. 2015 Jun;28(3):253-8.

Alam T, Reed T, Sieth J, Kumar N, Miller LG, Eells S, Boyle-Vavra S, Daum RS, David MZ. Whole Genome sequencing demonstrates that MRSA USA300 is transmitted primarily in the household. mBio. 2015 Mar 10;6(2):e00054.

Boyle-Vavra S, Li X, Alam MT,  Read TD, Jean C. Lee JC, Sieth J, David MZ, Kumar N, Eells SJ, Miller LG, Dobbins G, Boxrud DJ, Chambers HF, Lynfield R, Daum RS. USA300 and USA500 lineages of Staphylococcus aureus do not produce a capsular polysaccharide due to conserved mutations in the cap5 locus. mBio. 2015 Apr 7;6(2). pii: e02585-14.

Kumar N, David MZ, Boyle-Vavra S, Sieth J, Daum RS. High Staphylococcus aureus colonization prevalence among patients with skin and soft tissue infections and controls in an urban emergency department. J Clin Microbiol. 2015
Mar;53(3):810-5.

Hemmige V, McNulty M, Silverman E, David MZ. Predictors of skin and soft
tissue infections in HIV-infected outpatients in the community-associated
methicillin-resistant Staphylococcus aureus era. Eur J Clin Microbiol Infect Dis.
2015 Feb;34(2):339-47.

Miller LG, Eells SJ, David MZ, Ortiz N, Taylor AR, Kumar N, Cruz D,
Boyle-Vavra S, Daum RS. Staphylococcus aureus skin infection recurrences among household members: An examination of host, behavioral, and pathogen-level predictors. Clin Infect Dis. 2015 Mar 1;60(5):753-63.

2014
Jones MB, Montgomery CP, Boyle-Vavra S, Shatzkes K, Maybank R, Frank BC,
Peterson SN, Daum RS. Genomic and transcriptomic differences in community
acquired methicillin resistant Staphylococcus aureus USA300 and USA400 strains. BMC Genomics. 2014 Dec 19;15(1):1145.

David MZ, Siegel JD, Henderson J, Leos G, Lo K, Iwuora J, Porsa E, Schumm LP, Boyle-Vavra S, Daum RS. A randomized, controlled trial of chlorhexidine-soaked cloths to reduce methicillin-resistant and methicillin-susceptible Staphylococcus aureus carriage prevalence in an urban jail. Infect Control Hosp Epidemiol. 2014 Dec;35(12):1466-73.

Eells SJ, David MZ, Taylor A, Ortiz N, Kumar N, Sieth J, Boyle-Vavra S, Daum
RS, Miller LG. Persistent environmental contamination with USA300
methicillin-resistant Staphylococcus aureus and other pathogenic strain types in
households with S. aureus skin infections. Infect Control Hosp Epidemiol. 2014
Nov;35(11):1373-82.

Wilder JR, Wegener DT, David MZ, Macal C, Daum R, Lauderdale DS. A national survey of skin infections, care behaviors and MRSA knowledge in the United States. PLoS One. 2014 Aug 19;9(8):e104277.

David MZ, Siegel JD, Henderson J, Leos G, Lo K, Iwuora J, Taylor AR, Zychowski DL, Porsa E, Boyle-Vavra S, Daum RS. Hand and nasal carriage of discordant Staphylococcus aureus isolates among urban jail detainees. J Clin Microbiol. 2014 Sep;52(9):3422-5.

Macal CM, North MJ, Collier N, Dukic VM, Wegener DT, David MZ, Daum RS, Schumm P, Evans JA, Wilder JR, Miller LG, Eells SJ, Lauderdale DS. Modeling the transmission of community-associated methicillin-resistant Staphylococcus aureus: a dynamic agent-based simulation. J Transl Med. 2014 May 12;12:124.

David MZ, Daum RS, Bayer AS, Chambers HF, Fowler VG Jr, Miller LG, Ostrowsky B, Baesa A, Boyle-Vavra S, Eells SJ, Garcia-Houchins S, Gialanella P, Macias-Gil R, Rude TH, Ruffin F, Sieth JJ, Volinski J, Spellberg B. Staphylococcus aureus bacteremia at 5 US academic medical centers, 2008-2011: significant geographic variation in community-onset infections. Clin Infect Dis. 2014 Sep 15;59(6):798-807.

Greenberg JA, David MZ, Pitrak DL, Hall JB, Kress JP. Prior infections are
associated with increased mortality from subsequent blood-stream infections among patients with hematological malignancies. Eur J Clin Microbiol Infect Dis. 2014 Sep;33(9):1615-21.

Chambers HF, Bartlett JG, Bonomo RA, Chiou C, Cosgrove SE, Cross HR, Daum RS, Downing M, Evans SR, Knisely J, Kreiswirth BN, Lautenbach E, Mickley BS, Patel R, Pettigrew MM, Rodvold KA, Spellberg B, Fowler VG Jr. Antibacterial resistance leadership group: open for business. Clin Infect Dis. 2014 Jun;58(11):1571-6.

Montgomery CP, Daniels M, Zhao F, Alegre ML, Chong AS, Daum RS. Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A. Infect Immun. 2014 May;82(5):2125-34.

Larsen J, David MZ, Vos MC, Coombs GW, Grundmann H, Harbarth S, Voss A, Skov RL. Preventing the introduction of methicillin-resistant Staphylococcus aureus into hospitals. Journal of Global Antimicrobial Resistance. 2014;2(4):260-8.

David MZ, Cadilla A, Boyle-Vavra S, Daum RS. Replacement of HA-MRSA by CA-MRSA infections at an academic medical center in the midwestern United States, 2004-5 to 2008. PLoS One. 2014 Apr 22;9(4):e92760.

Greenberg JA, David MZ, Hall JB, Kress JP. Immune dysfunction prior to Staphylococcus aureus bacteremia is a determinant of long-term mortality. PLoS
One. 2014 Feb 5;9(2):e88197.

David MZ, Daum RS. Applying a new technology to an old question: whole-genome sequencing and Staphylococcus aureus acquisition in an intensive care unit. Clin Infect Dis. 2014 Mar;58(5):619-21.

2013
David MZ, Daum RS. Update on epidemiology and treatment of MRSA Infections in children. Curr Pediatr Rep. 2013 Sep 1;1(3):170-181.

David MZ, Siegel J, Lowy FD, Zychowski D, Taylor A, Lee CJ, Boyle-Vavra S,
Daum RS. Asymptomatic carriage of sequence type 398, spa type t571
methicillin-susceptible Staphylococcus aureus in an urban jail: a newly emerging,
transmissible pathogenic strain. J Clin Microbiol. 2013 Jul;51(7):2443-7.

Montgomery CP, Daniels MD, Zhao F, Spellberg B, Chong AS, Daum RS. Local
inflammation exacerbates the severity of Staphylococcus aureus skin infection.
PLoS One. 2013 Jul 5;8(7):e69508.

Misiura A, Pigli YZ, Boyle-Vavra S, Daum RS, Boocock MR, Rice PA. Roles of two large serine recombinases in mobilizing the methicillin-resistance cassette
SCCmec. Mol Microbiol. 2013 Jun;88(6):1218-29.

Dukic VM, Lauderdale DS, Wilder J, Daum RS, David MZ. Epidemics of
community-associated methicillin-resistant Staphylococcus aureus in the United
States: a meta-analysis. PLoS One. 2013;8(1):e52722.

David MZ, Taylor A, Lynfield R, Boxrud DJ, Short G, Zychowski D, Boyle-Vavra
S, Daum RS. Comparing pulsed-field gel electrophoresis with multilocus sequence typing, spa typing, staphylococcal cassette chromosome mec (SCCmec) typing, and PCR for panton-valentine leukocidin, arcA, and opp3 in methicillin-resistant Staphylococcus aureus isolates at a U.S. Medical Center. J Clin Microbiol. 2013 Mar;51(3):814-9.

David MZ, Daum RS. Reply to Lewis et al. Infect Control Hosp Epidemiol. 2013 Jan;34(1):106-7.
Lee BY, Singh A, David MZ, Bartsch SM, Slayton RB, Huang SS, Zimmer SM,
Potter MA, Macal CM, Lauderdale DS, Miller LG, Daum RS. The economic burden of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). Clin Microbiol Infect. 2013 Jun;19(6):528-36.

Boyle-Vavra S, Yin S, Jo DS, Montgomery CP, Daum RS. VraT/YvqF is required for methicillin resistance and activation of the VraSR regulon in Staphylococcus
aureus. Antimicrob Agents Chemother. 2013 Jan;57(1):83-95.

2012

David MZ, Zychowski DL, Taylor A, Lynfield R, Boxrud D, Boyle-Vavra S, Daum RS.
Comparing typing methods in U.S. clinical MRSA isolates:  spa, PFGE, MLST, SCCmec, arcA, opp3, and PVL, Journal of Clinical Microbiology, in press, December 2012.

VM, Wilder J, Daum RS, Lauderdale DS, David MZ. Estimating the epidemic curve
for CA-MRSA in the United States. PLoS ONE,in press, November 21, 2012. 

Miller LG, Eells SJ, Taylor AR, David MZ, Ortiz N, Zychowski D, Kumar N, Cruz D, Boyle-Vavra S, Daum RS. Staphylococcus aureus colonization among household contacts of patients with skin infections: Risk factors, strain discordance, and complex ecology. Clinical Infectious Diseases 2012 Jun;54(11):1523-1535.

David MZ, Medvedev S, Hohmann S, Ewigman B, Daum RS. Increasing burden of methicillin-resistant Staphylococcus aureus hospitalizations at US academic medical centers. Infection Control and Hospital Epidemiology 2012;33(8); electronically published June 11, 2012.

Lee BY, Singh A, David MZ, McGlone SM, Bailey RR, Huang SS, Zimmer SM, Potter MA, Macal CM, Lauderdale DL, Miller LG, Daum RS. ;The economic burden of community associated methicillin-resistant Staphylococcus aureus (CA-MRSA). Clinical Microbiology and Infection, published ahead-of-print May 21, 2012.

Watkins RR, David MZ, Salata RA. Current concepts on the virulence mechanisms of methicillin-resistant Staphylococcus aureus. Journal of Medical Microbiology, published ahead-of-print June 28, 2012.

Skov R, Christiansen K, Dancer SJ, Daum RS, Dryden M, Huang YC, Lowy FD. Update on the prevention and control of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA). International Journal of Antimicrobial Agents 2012 Mar;39(3):193-200.

David MZ, Rudolph KM, Hennessey TB, Zychowski DL, Asthi K, Boyle-Vavra S, Daum RS. MRSA USA300 at Alaska Native Medical Center, Anchorage, Alaska, USA, 2000-2006. Emerging Infectious Diseases 2012;18:105-8.

Gould IM, David MZ, Esposito S, Garau J, Lina G, Mazzei T, Peters G. New insights into meticillin-resistant Staphylococcus aureus (MRSA) pathogenesis, treatment and resistance. Int J Antimicrob Agents 2012 Feb;39(2):96-104.

Daum RS, Spellberg B. Progress Toward a Staphylococcus aureus Vaccine. Clincal Infectious Diseases 2012 Feb;54(4):560-7.

2011 

Myers PJ, Marcinak J, David MZ, Zychowski DL, Boyle-Vavra S, Weber S, Daum RS. Universal admission screening for methicillin-resistant Staphylococcus aureus (MRSA) in a level IIID neonatal intensive care unit (NICU): the first 9 months. Infection Control and Hospital Epidemiology 2011;32:398-400.

David MZ, Boyle-Vavra S, Zychowski DL, Daum RS. Methicillin-Susceptible Staphylococcus aureus as a Predominantly Healthcare-Associated Pathogen: A Possible Reversal of Roles? PLoS One. 2011 Apr 13;6(4):e18217

Dukic VM, David MZ, Lauderdale DS. Internet Queries and MRSA Surveillance. Emerging Infectious Diseases. 2011;17(6):1068-1070.

Keane E. National group releases first guidelines for the treatment of MRSA. Medill Reports: Chicago. Jan. 12, 2011.

Cadilla A, David MZ, Daum RS, Boyle-Vavra S. Association of High-Level Mupirocin Resistance and Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus at an Academic Center in the Midwestern United States. J Clin Microbiol. 2011 Jan;49(1):95-100.

2010

David MZ, Daum RS. Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev. 2010 Jul;23(3):616-87.

Hoehn KS, Capouya JD, Daum RS, Glikman D, Gossett JG, Hafzalah M, Johnson D, Marcinak J. Lemierre-like syndrome caused by community-associated methicillin-resistant Staphylococcus aureus complicated by hemorrhagic pericarditis. Pediatric Critica Care Medicine 2010;11(3):e32-35.

Macario E, Daum RS, Eells SJ, Miller LG. Using cognitive interviews to refine a household contacts survey on the epidemiology of community-associated methicillin resistant Staphylococcus aureus. Journal of Infection Prevention 2010;11(2):44-48.

2009

Daum RS. Epidemic Community Associated Methicillin Resistant Staphylococcus aureus Infections. Increasingly, Everyone's Problem. J AAPOS. 2009, 13:225-6.

Klein E, Smith DL, Laxminarayan R. Community-associated methicillin-resistant Staphylococcus aureus in outpatients, United States 1999-2006. Emerging Infectious Diseases 2009;15(12). Available from http://www.cdc.gov/EID/content/15/12/1925.htm

Crawford SE, David MZ, Glikman D, King KJ, Boyle-Vavra S, Daum RS. Clinical importance of purulence in methicillin-resistant Staphylococcus aureus skin and soft tissue infections. J Am Board Fam Med 2009;22:647-654.

Burman W, Daum R. Grinding to a halt: The effects of the increasing regulatory burden on research and quality improvement efforts. Clinical Infectious Diseases (CID) 2009;49:328-335.

2008

David MZ, Rudolph KM, Hennessey TB, Boyle-Vavra S, Daum RS. Molecular epidemiology of methicillin-resistant Staphylococcus aureus in rural southwest Alaska. Emerging Infectious Diseases. 2008;14(11):1693-9.

Daum RS. Removing the Golden Coat of Staphylococcus aureus. N Eng J Med Clinical Implications of Basic Research), 359:85-87, 2008.

Crawford SE, Daum RS. Bacterial pneumonia, lung abscess, and empyema. In Taussig LM, Landau LI, Le Souef PN, Morgan WJ, Martinez FD, Sly PD. Pediatric Respiratory Medicine, Mosby Elsevier, Philadelphia, Pa, 2008, pp 501-554.

Daum RS.  Staphylococcus aureus vaccines.  In Plotkin S, Orenstein W, Offit P.  Vaccines, 5th edition, 2008, pp 1307-1315.

David MZ, Daum RS.  Endemic methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a large urban jail: risk factors and recurrence rates.  J Clin Micro 2008;46:3222-3227.

David MZ, Glikman D, Crawford SE, Peng J, King KJ, Hostetler MA, Boyle-Vavra S, Daum RS.  What is community-associated methicillin-resistant Staphylococcus aureusJ Infect Dis 2008;197:1235-1243.

Glikman D, Siegel JD, David MZ, Okuro NM, Boyle-Vavra S, Dowell ML, Daum RS.  Complex molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) isolates from children with cystic fibrosis in the era of epidemic community-associated MRSA. Chest 2008;133:1381-1387.

Lowell G, Daum RS. Staphylococcus aureus infections. In Long SS, Pickering LK, Prober CG. Principles and Practice of Pediatric Infectious Diseases, 3rd edition, 2008, pp 679-693.

2007

Daum RS. The treatment of community-associated methicillin-resistant Staphylococcus aureus infections. N Eng J Med 2007;357:380-390.

Maree C, Daum RS, Boyle-Vavra, Miller LG.  A rapid increase in "community-associated" methicillin-resistant Staphylococcus aureus isolates causing healthcare-associated Infections.  Emerg Inf Dis 2007;13:236-242.

2006

Crawford S, Boyle-Vavra S, Daum RS.  Community associated methicillin-resistant Staphylococcus aureus.  In Scheld M, Hooper D, Hughes JM, eds. Emerging Infections 7, 2006, pp 153-170.

Crawford SE, Daum RS. Therapy of staphylococcal infections.  In Burg, Ingelfinger J, Polin, Gershon A.  Current Pediatric Therapy, 18th edition, in press, 2006.

David MZ, Crawford SE, Boyle-Vavra S, Kim DC, Daum RS.  Comparing antibiotic resistance among community-associated methicillin-resistant Staphylococcus aureus isolates from adults and children.  Emerg Inf Dis 2006;12:631-637.

Gorwitz RJ, Jernigan DB, Powers JH, Jernigan JA and Participants in the Centers for Disease Control and Prevention-Convened Experts’ Meeting on Management of MRSA in the Community (RS Daum, Participating author), 2006. Available at http://www/cdc/gov/ncidod/dhqp/ar-mrsa-ca.html.

2005

Adem PV, Montgomery CP, Husain AN, Koogler TK, Arangelovich V, Humilier M, Boyle-Vavra S, Daum RS.  Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children.  N Eng J Med 2005;353:1245-1251.

Crawford SE, Daum RS.  Epidemic community-associated methicillin-

resistant Staphylococcus aureus: modern times for an ancient pathogen.  Pediatr Inf Dis 2005;24:459-460.

Mongkolrattanothai K, Daum RS.  Impact of community-associated methicillin-resistant Staphylococcus aureus on management of skin and soft tissue infections in children.  Curr Infect Dis Reports 2005;7:381-389.

2004

Gregerson A, Daum RS. Staphylococcus aureus Vaccine.  In Plotkin SA, Orenstein WA (eds), Vaccines. 4th edition.  WB Saunders Co, Philadelphia, 2004. pp 1347–1355.

2003

Seal JB, Moreira B, Bethel CD, Daum RS.  Antimicrobial resistance in Staphylococcus aureus at the University of Chicago Hospitals: 15-year longitudinal assessment in a large university-based hospital.  Infect Control Hosp Epidem 2003;42:403-408.

2001

Daum RS, Seal J.  Evolving antimicrobial therapy for Staphylococcus aureus infections: our backs to the wall.  Crit Care Med 2001;29:N92-N96 (suppl).

Hussain FM, Boyle-Vavra S, Daum RS.  Community-acquired methicillin-resistant Staphylococcus aureus colonization in healthy children attending an outpatient pediatric clinic.  Pediatr Infect Dis J 2001;20:763-767.

2000

Hussain FM, Boyle-Vavra S, Bethel CD, Daum RS.  Current trends in community-acquired methicillin-resistant Staphylococcus aureus at a tertiary care pediatric facility.  Pediatr Infect Dis J 2000;19:1163-1166.

Lin PL, Oram RJ, Lauderdale D. Dean R, Daum RS.  Knowledge of CDC guidelines for the use of vancomycin in a large tertiary care children’s hospital.  J Pediatr 2000;137:694-700.

1999

Jain A, Daum RS.  Staphylococcal infections in children. Part 1.  Pediatr in Rev 1999;20:183-191.

Jain A, Ben-Ami T, Daum RS.  Staphylococcal infections in children. Part 2.  Pediatr in Rev 1999;20:219-227.

Jain A, Daum RS.  Staphylococcal infections in children. Part 3.  Pediatr in Rev 1999;20:261-265.

Suggs AH, Maranan MC, Boyle-Vavra S, Daum RS.  Methicillin resistant and borderline methicillin-resistant asymptomatic Staphylococcus aureus colonization in children without identifiable risk factors.  Pediatr Infect Dis J 1999;18:410-414.

1998

Daum RS.  Community-acquired methicillin-resistant Staphylococcus aureus infections in children.  Pediatr Infect Dis J 1998;17:745-746.

Herold BC, Immergluck LC, Maranan MC, Lauderdale DS, Gaskin RE, Boyle-Vavra S, Leitch CD, Daum RS.  Community acquired methicillin resistant Staphylococcus aureus infections in children without traditional risk factors for infection.  JAMA 1998;279:593-598.

1997

Maranan M, Moreira B, Boyle-Vavra S, Daum RS.  Antimicrobial resistance in the staphylococci.  Molecular mechanisms, epidemiology and clinical relevance.  Inf Dis Clin NA 1997;11:813-849.

1995

Moreira B, Daum RS.  Antibiotic resistance in the staphylococci.  Pediatr Clin NA 1995;42:619-648.